Hassan MB, Stern C, Flanagan EP, et al. - Researchers conducted this retrospective, population-based cohort to re-assess the population-based incidence of optic neuritis in the era of aquaporin-4 (AQP4)-immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which are biomarkers of optic neuritis distinct from multiple sclerosis (MS). Between January 1, 2000, and December 31, 2018, all residents of Olmsted County, Minnesota diagnosed with optic neuritis were included. One hundred ten people were diagnosed with optic neuritis providing an annual incidence of 3.9 per 100,000. At a population level, AQP4-IgG and MOG-IgG account for 9% of optic neuritis and are related to recurrent attacks, but MOG-IgG optic neuritis has a better visual outcome than AQP4-IgG optic neuritis.