Population attributable fractions for risk factors for dementia in low-income and middle-income countries: An analysis using cross-sectional survey data
The Lancet Global Health Apr 19, 2019
Mukadam N, et al. - In this investigation, researchers calculated population attributable fractions (PAFs) for dementia in selected low- and middle-income countries (LMICs) to identify potential targets for prevention of dementia in these nations. To this end, they analyzed cross-sectional data obtained from the 10/66 Dementia Research surveys of representative populations in India, China, and six Latin America countries, using identical methods for determining the risk factor in each country. Investigators found that the overall weighted PAF for potentially modifiable risk factors for dementia was 39.5% in China, 41.2% in India, and 55.8% in the Latin America. In India, China, and Latin American countries, the potential for dementia prevention is large and greater than in high-income countries. Less early-life education, hypertension, hearing loss, obesity, and physical inactivity have particularly high PAFs and could be initial targets for strategies to prevent dementia.
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