Petrykiv SI, et al. - This study investigated if uptitrating the dose of drug, changing the mode of intervention (with drugs from similar or different classes), or lowering dietary sodium intake, therapy resistance to renin-angiotensin-aldosterone system inhibitors (RAASi) can be overcome. For this purpose, researchers meta-analyzed individual responses to different modes of interventions. Findings demonstrated that those who exhibited a poor response to one dose or type of RAASi also responded poorly to higher doses, other types of RAASi or nonsteroidal anti-inflammatory drugs (NSAIDs), or a reduction in dietary salt intake.