Dhollander A, Toanen C, Beaufils P, et al. - Researchers assumed that the application of an acellular polyurethane scaffold in symptomatic partial meniscal defects results in both midterm pain relief and improved function. In a prospective, single-arm, multicentric study with a minimum 5-year follow-up, a total of 155 patients with symptomatic partial meniscal defects (101 medial and 54 lateral) were implanted with a polyurethane scaffold. Researchers evaluated clinical outcomes with the visual analog scale for pain, International Knee Documentation Committee, Lysholm Knee Scale, and Knee injury and Osteoarthritis Outcome Score at baseline and at 2- and 5-year follow-up. The knee joint, meniscal implant, and meniscal extrusion were tested by using MRI. They also conducted a Kaplan-Meier time-to-treatment failure analysis. The data exhibited that in patients with segmental medial meniscus deficiency over 5 years after implantation, the polyurethane meniscal implant is able to improve knee joint function and significantly reduce pain. At midterm follow-up, the MRI appearance of this scaffold is different than the original meniscal tissue with a still increased signal intensity and a reduction in size in comparison with the normal meniscus in the majority of the cases. It was shown that treatment survival rates of 87.9.9% of the medial scaffolds and 86.1% of the lateral scaffolds in the present study compare similarly to those published concerning meniscal allograft transplantation after total meniscectomy.