Stapleton CP, et al. - In view of an increased risk of non-melanoma skin cancer (NMSC) among renal transplant recipients vs the general population, researchers sought to demonstrate the utility of polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of NMSC in a general, nontransplant setting, in predicting risk of and time to post-transplant skin cancer. From published squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) nontransplant GWAS, they chose genetic variants reaching predefined P-value thresholds. These GWAS were used to calculate BCC and SCC PRS for each sample across three European ancestry renal transplant cohorts (n = 889); the PRS were tested as predictors of case:control status and time to NMSC posttransplant. For case:control status and time to NMSC posttransplant, outcomes suggest there is predictive value in PRS of nontransplant NMSC. The most significant predictor of time to posttransplant NMSC was SCC PRS at P-value threshold 1 × 10⁻⁵.