Barr PB, et al. - Researchers examined the association between genome-wide polygenic scores (GPS) for alcohol consumption and alcohol misuse. In addition, they examined how romantic relationships influence these GPS (gene-environment interaction; GxE), and if GxE results are consistent across sex. They used linear mixed-effects models to inquire links between genome-wide polygenic scores, relationship status, and alcohol use/misuse. A subset of Finnish Twin Study (FinnTwin12) with the complete interview and genetic data (N=1,201, 54% female) was included. Findings suggest a predictive value of GPS for drinking frequency, intoxication frequency, and alcohol dependence symptoms. The association between genetic predisposition and drinking, high-risk drinking, and alcohol problems was reduced among those in a romantic relationship. However, only males experience the protective effect against high-risk drinking, relating to earlier findings suggesting that males benefit more from romantic partnerships.