Podocyte antigen staining to identify distinct phenotypes and outcomes in membranous nephropathy: a retrospective multicenter cohort study
American Journal of Kidney Diseases Jul 15, 2020
Hanset N, Aydin S, Demoulin N, et al. - A multicenter retrospective cohort study was performed to evaluate the correlation of podocyte antigen staining with membranous nephropathy (MN) clinical phenotype and outcomes. Researchers distinguished a total of 177 consecutive patients with MN unrelated to lupus erythematosus, from a cohort of 3,875 native kidney biopsies conducted in the Belgian UCLouvain Kidney Disease Network between 2000 and 2018. They performed Kaplan-Meier estimates and Cox regression analyses to evaluate time to cancer and kidney failure. The outcomes reveal the relative prevalence of subgroups of MN, and guide the hypothesis that a new categorization of MN based on podocyte antigen staining might be clinically relevant.
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