Zobel EH, et al. – In this study, researchers assessed individual responses to liraglutide in six cardio-renal risk factors to determine whether responses in one risk factor are linked to changes in other risk factors (cross-dependency). Good glycated hemoglobin (HbA_1c) responders showed similar changes in other risk factors analyzed as low responders in the liraglutide-treated group. Good weight responders demonstrated a greater reduction in HbA_1c more vs low weight responders, but similar changes were observed in the other risk factors. Good and low responders in systolic blood pressure, urine albumin-to-creatinine ratio, low density lipoprotein-cholesterol, or estimated glomerular filtration rate showed similar changes in other risk factors. Overall, liraglutide treatment response is largely individual. Apart from the association between weight and HbA_1c reduction, there was no obvious cross-dependencies in the response to the risk factor.