Elgendy MM, Durgham R, Othman HF, et al. - Given that prophylactic platelet transfusion has become a common practice in the management of thrombocytopenia in preterm infants to reduce the risk of bleeding, researchers performed this cross-sectional study to report the prevalence of platelet transfusion among preterm infants with thrombocytopenia and to evaluate the correlation of platelet transfusion with mortality and morbidity in this population. All preterm infants delivered nationally with birth weight (BW) < 1,500 g or gestational age < 32 weeks were involved. The study included 1,780,299 infants, with 22,609 (1.27%) diagnosed with thrombocytopenia and 5,134 (22.7%) receiving platelet transfusion. Platelet transfusion was linked to an increase in mortality, retinopathy of prematurity, severe intraventricular hemorrhage, median length of hospital stays, and hospitalization costs. Findings suggested an association of platelet transfusion with increased mortality and comorbidities in premature infants. Over the course of the study, there was an increase in the use of platelet transfusions.