Zhu Y, Li M, Rahman ML, et al. - Researchers assessed a subsequent risk of gestational diabetes mellitus (GDM) in relation to individual plasma phospholipid n-3 and n-6 polyunsaturated fatty acids (PUFAs) in early to midpregnancy in this longitudinal analysis including 107 women with GDM and 214 matched non-GDM women within the prospective National Institute of Child Health and Human Development Fetal Growth Studies–Singleton Cohort in the United States. In the development of GDM, primarily endogenously metabolized plasma phospholipid n-6 PUFAs including gamma-linolenic acid, dihomo-gamma-linolenic acid, and docosatetraenoic acid in early to midpregnancy may be suggested to have a potential role. Null results on primarily diet-derived n-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and n-6 linoleic acid did not offer strong proof to imply an advantageous role in GDM prevention, although not dismissing the potential advantage of EPA and DHA on glucose–insulin homeostasis given the inverse links with insulin-resistance markers. In order to determine the distinct pathophysiologic roles of individual circulating PUFAs in glucose homeostasis in pregnancy, it is important to evaluate individual circulating PUFAs.