Shi L, Brunius C, Johansson I, et al. - In a case-control study nested within the Västerbotten Intervention Programme, using untargeted liquid chromatography–mass spectrometry metabolomics, baseline plasma samples from 421 case-control pairs and samples from a subset of 149 pairs at a 10-year follow-up were assessed to identify plasma metabolites related to boiled or filtered coffee consumption, and to determine their relationship with type 2 diabetes (T2D) risk in Swedish adults. A total of 24 and 32 metabolites were correlated with boiled or filtered coffee consumption, respectively. These plasma metabolites specifically related to boiled or filtered coffee consumption might be utilized as particular biomarkers, noted the researchers. Their findings supported a protective role of habitual consumption of filtered coffee on T2D development. Moreover, the lack of correlation for boiled coffee consumption could be because of the lack of a protective influence of boiled coffee or because of the restricted number of boiled coffee consumers in this population; however, further study is needed.