Hýža M, Šilhán P, Češková E, et al. - Researchers aimed at determining the real effectiveness of long-acting injectable antipsychotics (LAI AP). As antipsychotic efficacy in schizophrenia depends on its availability in the body, they retrospectively evaluated plasma levels of LAI AP. In the observed cohort of patients, the most frequently used drug was flupentixol decanoate (n = 23), followed by fluphenazine decanoate (n = 7), haloperidol decanoate (n = 5), paliperidone palmitate (n = 3), and risperidone microspheres (n = 2). In these patients, there was a surprisingly high incidence of plasma levels under the therapeutic reference range. Notwithstanding individual variability in pharmacokinetics, it appears that in usual clinical practice, LAI AP may be underdosed.