Wang XJ, Wang Z, Zhang ZT, et al. - In view of the necessity for more efficient biomarkers for the timely and accurate diagnosis of infected nonunion, researchers here evaluated and compared the performance of plasma fibrinogen, which is reported to have an important role in mediating inflammation in bacterial infections, and other traditional blood markers for the diagnosis of infected nonunion. Among 146 retrospectively studied patients who underwent surgery for primary nonunion, 55 had infected nonunion and 91 had aseptic nonunion. Plasma fibrinogen, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and white blood cell (WBC) count were analyzed in the preoperative assessment. Patients with infected nonunion showed significantly higher plasma fibrinogen values relative to those observed in patients with aseptic nonunion. Per findings, plasma fibrinogen exhibits good diagnostic ability for the detection of infected nonunion relative to the traditional markers of infection. They suggest plasma fibrinogen has the potential as a practical and cost-efficient biomarker for diagnosing infected nonunion.