Verberk IMW, et al. - In cognitively normal individuals with subjective cognitive decline (SCD), researchers examined the connection of plasma amyloid beta (Abeta)40, Abeta42 and total tau (tTau) with the presence of Alzheimer's pathological changes by analyzing data from 248 subjects with SCD from the SCIENCe project and Amsterdam Dementia Cohort. Findings suggested an association of low plasma ratio with clinical progression to mild cognitive impairment (MCI) or dementia. In cognitively normal individuals with SCD, plasma Abeta42/Abeta40 ratio could be a promising pre-screener for identifying Alzheimer's pathological changes.