Kaze AD, Musani SK, Bidulescu A, et al. - In a community‐based sample of African American (AAs), researchers sought to explore the connection between plasma biomarkers including leptin, adiponectin, adiponectin‐to‐leptin ratio and high‐sensitivity C‐reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre‐diabetes or diabetes). Data were analyzed from 3,223 candidates without type 2 diabetes at baseline (2000–2004) who attended ≥ 1 follow‐up visit. It was noted that 46.4% developed glycaemic progression (n = 1,495) over a median of 7 years. The findings in this large community-based cohort of AAs suggest that high plasma leptin and hsCRP levels, as well as low adiponectin and adiponectin‐to‐leptin ratio, are associated with an increased risk of glycaemic progression. The findings suggest that these biomarkers may be useful in predicting and preventing glycemic progression in this high‐risk population.