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Planned induction vs spontaneous delivery among women using prophylactic anticoagulation therapy: A retrospective study

BJOG: An International Journal of Obstetrics and Gynaecology Apr 19, 2020

Rottenstreich A, Zacks N, Kleinstern G, et al. - Via this retrospective cohort study, researchers sought to determine the outcomes of planned induction of labor vs spontaneous onset of labor among women receiving antepartum prophylactic low‐molecular weight heparin therapy and undergoing a trial of vaginal delivery. They analyzed data from 199 women; of these, 78 (39.2%) were admitted following spontaneous onset of labor and 121 (60.8%) underwent planned induction of labor. Outcomes revealed a higher risk of postpartum thrombotic events in correlation with planned induction of labor vs spontaneous onset of labor (4 of 121 (3.3%) vs. 0 of 78 (0%)); this is seemed to be related to prolonged duration of anticoagulation interruption. The difference was, however, not statistically significant. Comparable rates of bleeding complications were observed in correlation with allowing spontaneous onset of labor, and there was only a low proportion (9 of 78, 11.5%) that was not eligible to receive neuraxial anesthesia.

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