Placental morphology and the prediction of underlying cardiovascular risk factors
European Journal of Obstetrics & Gynecology and Reproductive Biology Jun 07, 2021
Zaza A, Pudwell J, Bainbridge S, et al. - Researchers sought to determine the association between placental size and cardiovascular risk when evaluated at six months postpartum in females who encountered preeclampsia. Preeclamptic women were divided, based on maternal clinical and biochemical cardiovascular risk factors, into high vs low lifetime cardiovascular disease risk profiles at six months postpartum. It was found that placental morphometric measurements did not differ significantly between females who were screened as having a high vs low lifetime risk profile for cardiovascular disease at six months postpartum. An elevated odds of high lifetime cardiovascular disease risk was observed in relation to a low placenta to birth weight ratio (<15%), as noted using multivariable modelling that controlled for maternal age, pre-pregnancy BMI, gestational age at delivery, and severity of preeclampsia. Overall, the results unveiled clinical measurements that are obtainable at the time of delivery which may aid in recognizing specific women for whom postpartum cardiovascular risk screening and intervention may prove to be most beneficial.
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