Verma S, et al. - This study was performed with the aim to immune-localise and morphometrically analyse CHOP and hypoxia inducible factor-1α (HIF-1α) within the placenta of normotensive and pre-eclamptic pregnancies and concomitantly quantify syncytiotrophoblast released microvesicles in maternal circulation. In this study, compared to normotensive pregnancies, increased placental expression of HIF-1α and CHOP was observed in preeclampsia which correlate to their increased syncytiotrophoblast microvesicles concentration in maternal circulation. Findings thereby suggested that placental hypoxia and ER stress were interrelated contributory factors to the pathogenesis of PE and the consequential release of placental derived debris into the maternal circulation.