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Placental growth factor as an indicator of maternal cardiovascular risk after pregnancy

Circulation Feb 21, 2019

Benschop L, et al. - Authors investigated whether low angiogenic placental growth factor levels, particularly in mid-pregnancy, can identify women at risk for pregnancy complications as well as women with greater cardiovascular risk factor burden following pregnancy irrespective of pregnancy outcome in this population-based prospective cohort study that included 5,529 women. According to findings, eomen with mid-pregnancy PlGF in the lowest quartile had a larger aortic root diameter (AOD), left atrial diameter (LAD), left ventricular (LV) mass, and systolic blood pressure (SBP) 6 years post-pregnancy vs women with the highest PlGF. Furthermore, women with low PlGF in mid-pregnancy have a greater AOD, LAD, and LV mass, and higher SBP 6-9 following pregnancy vs women with higher PlGF, including those with uncomplicated pregnancies.

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