Ogata D, et al. - Authors assessed the effective use of fluorescence in situ hybridization (FISH) in the diagnosis of acral volar melanocytic lesions and determined if acral volar melanocytic lesions show characteristic molecular biological features of malignant melanoma (MM) via FISH. Findings suggested that in the diagnosis of early in situ MM when a typical parallel ridge pattern (PRP) was observed in an acral volar skin lesion with non-diagnostic histopathology, FISH using whole-slide digital imaging could be useful.