Sousa AW, Cabral ALB, Silva RA, et al. - In this cross‐sectional study, researchers compared adolescents with asthma and fixed airflow obstruction (FAO) and adolescents with asthma without FAO in terms of aerobic fitness, physical activity levels (PAL), muscle strength, and health‐related quality of life (HRQoL). The sample consisted of adolescents with asthma, both sexes, aged 12 to 18 years and were divided into two groups: FAO and non‐FAO groups. According to the Global Initiative for Asthma guidelines, the adolescents were diagnosed with asthma and underwent optimal pharmacological treatment for at least 12 months. There were no significant differences between FAO and non‐FAO groups regarding the peak oxygen uptake, sedentary time, upper limb muscle strength, lower limb muscle strength, or HRQoL.The FAO group, however, displayed greater maximal expiratory pressure than the non‐FAO group. The findings indicate that FAO does not affect aerobic fitness, PAL, peripheral muscle strength, or HRQoL in adolescents with asthma. Adolescents with asthma were, however, physically deconditioned.