Sater ZA, Jha A, Hamimi A, et al. - A retrospective case-control study was designed to explore the correlation between brown adipose tissue (BAT) activation and paragangliomas (PPGLs) clinical outcomes. At the National Institutes of Health (NIH), experts enrolled 342 individuals with PPGLs who assumed ¹⁸F-FDG PET/CT imaging. They evaluated 205 individuals scan by two blinded nuclear medicine physicians; 16 patients had BAT activation on ¹⁸F-FDG PET/CT. They picked 36 matched controls from the remaining 189 patients. Higher plasma NE levels were significantly associated with mortality in PPGLs in both groups. There was an association between the detection of BAT activity in PPGL patients with higher mortality. The outcomes demonstrated that BAT activation could either be catching or devoting to a state of elevated host stress that may forecast poor result in metastatic PPGL.