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Phenome‐wide analysis of short‐ and long‐run disease incidence following recurrent pregnancy loss using data from a 39‐year period

Journal of the American Heart Association Apr 24, 2020

Westergaard D, Nielsen AP, Mortensen LH, et al. - Researchers examined the disease risk following recurrent pregnancy loss (RPL). Further, they assessed whether cases with primary and secondary RPL differ in this risk. A cohort of 1,370,896 ever‐pregnant women (aged 12 to 40 years) was identified between 1977 and 2016 using population‐wide healthcare registries from Denmark. In this cohort, the criteria for RPL was fulfilled by 10,691 (0.77%) women (50.0% primary RPL). Analysis revealed RPL as a risk factor for a spectrum of disorders; the risk was different for primary and secondary RPL. Primary RPL was identified related with increased risk of subsequent cardiovascular disorders, including atherosclerosis, cerebral infarction, heart failure, and pulmonary embolism, as well as systemic lupus erythematosus, chronic obstructive pulmonary disease, anxiety, and obsessive‐compulsive disorder. Women with secondary RPL had no increased risk of cardiovascular disorders, but were noted to be at an increased risk of gastrointestinal disorders such as irritable bowel syndrome and intestinal malabsorption, as well as mental disorders and obstetric complications. Some associations could be explained with screening following RPL, however, the remaining findings indicate that RPL influences or shares cause with cardiovascular disorders, autoimmune disorders, and mental disorders.

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