Mose LS, et al. - In this comparative study, researchers examined whether different personality traits were exhibited by migraine patients vs patients with medication-overuse headache (MOH), recognized as a biobehavioral disorder, and whether these personality traits were different from a Danish normative sample. The NEO-Five-Factor-Inventory was finished, with an age-matched cohort of patients with episodic migraine (n=94) and patients with MOH (n=94). Multivariate regression models and sex-stratified comparisons were executed on patients′ raw scores of five personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness). In addition, the headache groups were compared with regard to personality traits to a Danish normative sample (n=1,032). Compared to female migraineurs, MOH females had significantly lower scores on extraversion, openness and conscientiousness. There were no differences in males. Both headache groups had a lower score on extraversion vs the normative sample, while MOH patients had statistically significant lower scores on conscientiousness and the migraine patients had a higher score. If confirmed in larger studies, this information may be used in clinical practice in personalized treatment.