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Persistent ventilation inhomogeneity after an acute exacerbation in preschool children with recurrent wheezing

Pediatric Allergy and Immunology Apr 19, 2020

Kowalik K, Dai R, Safavi S, et al. - Given that preschool children with recurrent wheezing suffer high morbidity, researchers ascertained if objective measures of asthma control like pulmonary function tests (PFTs) provide additional information to the clinical assessment. They enrolled children between 3 and 6 years old, with a history of recurrent wheezing in the previous year, and treated in an an observational cohort study for acute wheezing exacerbation in the emergency department (ED). Children received two outpatient visits: the first study visit within five days of the ED discharge and the second study visit 12 weeks after the ED visit. They conducted standardized symptom score [test for respiratory and asthma control in kids (TRACK)], multiple breath washout, spirometry, and clinical assessment at both visits. No association was found between PFT measures and TRACK scores at either visit. For a large proportion of preschoolers with recurrent wheezing, the lung clearance index shows a persistent postexacerbation deficit, indicating that symptom scores alone may not be adequate to track these children.

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