Tu XQ, Lai ZH, Zhang Y, et al. - In this study with 238 participants, researchers focused on the correlation between white matter hyperintensity and post-stroke depression (PSD) at 3 months, as well as examined gender disparities in the pathogenesis of PSD. They found in logistic regression that an independent risk for PSD at 3 months was conferred by the presence of periventricular white matter hyperintensity (PVWMH) at baseline in male patients. In further subgroup analysis, they found a link of PVWMH with late-onset PSD in men, but not with continuous depression 3 months post-stroke. There was a greater probability of experiencing PSD at 3 months, particularly late-onset PSD, in male acute stroke patients with PVWMH at baseline. These findings demonstrate that PSD pathogenesis may be impacted by gender differences.