Tasic L, Larcerda ALT, Pontes JGM, et al. - Considering their previous study proposing the value of proton magnetic resonance spectroscopy (¹H-NMR) in successfully discriminating schizophrenia (SCZ) and bipolar disorder (BD) patients from healthy control (HC) individuals, researchers identified metabolites present only in BD (as for instance the 2,3-diphospho-D-glyceric acid, N-acetyl aspartyl-glutamic acid, monoethyl malonate) or only in SCZ (as isovaleryl carnitine, pantothenate, mannitol, glycine, GABA) via treating ¹H-NMR data by chemometrics and performing principal component analysis and supervised partial least-squares discriminant analysis of the data. This set of potential biomarkers may assist in diagnosing these mental disorders and may permit the discrimination between SCZ and BD, and among these psychiatric patients and HC (as 6-hydroxydopamine was present in BD and SCZ but not in HC). They categorized 182 independent individuals into one of these three groups via assessing the presence or absence of these metabolites in blood. In addition, data suggested that in SCZ and BD, metabolic pathways disrupt, which may present novel and valuable information to support the explanation and/or novel insights into the neurobiology underlying these mental disorders.