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Peri‐complication diagnosis of hepatitis C infection: Risk factors and trends over time

Liver International Sep 25, 2020

Lapointe‐Shaw L, Chung H, Sander B, et al. - This study was intended to distinguish the frequency of and risk factors for Hepatitis C virus (HCV) diagnosis peri‐complication, which is within six months of an advanced liver disease complication. Between 2003 and 2014, researchers conducted a retrospective cohort study of Ontario residents diagnosed with chronic HCV infection. Researchers characterized HCV diagnosis peri‐complication as the occurrence of decompensated cirrhosis, hepatocellular carcinoma, or liver transplant within +/‐ 6 months of HCV diagnosis. They applied multivariable logistic regression to distinguish risk factors for peri‐complication diagnosis among all those diagnosed with HCV infection. This cohort enrolled 39,515 individuals with chronic HCV infection, of whom 4.2% (n=1,645) were diagnosed peri‐complication; these represented 31.6% of the 5,202 patients who developed complications in the follow‐up period. This study's findings demonstrate that over a quarter of HCV‐infected individuals with complications were diagnosed with peri‐complication. This problem elevated over time, implying a requirement to future expand HCV screening.

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