Gu J, Zhang S, Chen L, et al. - Individuals with systemic lupus erythematosus (SLE) are typically treated with total hip arthroplasty (THA) because of osteonecrosis of the femoral head (ONFH). This research assessed the outcome of THA in this patient group. Researchers retrospectively examined 92 THAs for patients with SLE and 92 THAs for age- and sex-matched patients suffering from ONFH due to nonrheumatic etiologies Both groups were treated with cementless THA and followed up for an average of 50.9 ± 30.6 months between January 2004 and January 2017. They further evaluated and compared the surgical outcomes and complications. Conducting THA for individuals with SLE in an inactive or stably active disease condition resulted in comparable postoperative Harris hip score and Mmental Component Summary Scale scores, a lower Physical Component Summary Scale score, and shorter-term postoperative complications in comparison with individuals with ONFH resulting from nonrheumatic diseases. Patients with SLE had a higher risk for postoperative complications. As per the data, THA was found to be safe and effective in patients with inactive or stably active SLE. Nevertheless, they still have an elevated risk of short-term complications.