de Klerk CM, et al. - In a cross-sectional study in the Dutch national screening program, researchers compared the accuracy of the two frequently used fecal immunochemical test (FIT) methods (FOB-Gold and OC-Sensor) in detecting advanced neoplasia (ie, colorectal cancer and advanced adenoma) across various thresholds. For this investigation, people who were screening-naive in 2016 (aged 55–75 years) living in the southwest region of the Netherlands were invited to use two different FIT assays on the same bowel movement. The accuracy of results in individuals undergoing colonoscopy did not differ significantly between the FITs, with an area under the receiver operating characteristic curve of 0.675 for FOB-Gold and 0.686 for OC-Sensor. The investigators noted that the two widely used FITs have significantly different distributions of reported hemoglobin concentration and yield different positivity rates at equal thresholds. However, they detect advanced neoplasia at a preset positive rate in the same way. When either FIT is implemented in a screening program, the desired positive rates that identify participants to be referred for colonoscopy should first be set, based on available resources and feasibility.