Shah SN, Grunwell JR, Mohammad AF, et al. - Experts aspired to explore whether plasma concentrations of eosinophil cationic protein (ECP), a marker of eosinophil activation, would be useful for detection of type 2 inflammation and would predict poorer asthma outcomes over 1 year. Children and adolescents 6 through 17 years (N = 256) with confirmed asthma finished a baseline visit and a follow-up visit at 12 months. Plasma ECP concentrations ranged from 0.03 to 413.61 ng/mL (median, 6.95 ng/mL) and were consistently linked to other markers of type 2 inflammation. Plasma ECP concentrations may be a useful marker of type 2 inflammation in children, assisting in the identification of children at high risk of recurrent exacerbations who may benefit from corticosteroid treatment. Additional markers, however, may be required to improve sensitivity for outcome detection.