Mazor M, Paul SM, Chesney MA, et al. - In this study, researchers examined the occurrence, severity, and distress associated with 32 co-occurring symptoms in 623 cancer survivors. In addition, they evaluated the phenotypic and stress characteristics associated with a higher symptom burden. Participants were asked to complete a demographic questionnaire, as well as measures of functional status, comorbidity, and global (Perceived Stress Scale) and cancer-related (Impact of Event Scale–Revised) stress. Cancer survivors described a high number of co-occurring symptoms of moderate severity and distress; however, there were no disease or treatment characteristics that were associated with a higher symptom burden. Symptoms like lack of energy, problems with sexual interest/activity, and hair loss, were most common, severe, and distressing. They observed a higher symptom burden in correlation with poorer functional status, a higher level of comorbidity, and a history of smoking as well as higher Perceived Stress Scale and Impact of Event Scale–Revised scores. These findings emphasized assessment for general and disease-specific stressors and provision of referrals for stress-management interventions.