Nabe-Nielsen K, et al. - Researchers examined the influence of perceived stress in midlife on the risk of dementia. Furthermore, they investigated how subgroups related to sex, age and employment status differ when reporting stress. In this longitudinal study, they assessed information on perceived stress from 10,814 participants (mean age 56.7 years) and followed them through Danish national registers for development of dementia. A combination of self-reported intensity and frequency of stress was assessed as perceived stress, and it was categorized into low (score 0–1), medium (score 2–4), and high stress (score 5–6). During the mean follow-up time of 13.8 years, dementia was reported in 1,519 participants. Participants reporting medium stress and high stress showed higher tendency to suffer dementia. Subgroups displayed no significant differences, although those who were employed at the time of reporting high stress had stronger association between stress and dementia. Outcomes thereby provide empirical support for an influence of perceived stress on the risk of dementia in old age.