Janku P, et al. - From a total of 160 women with preterm prelabor rupture of membranes (PPROM), noninvasively obtained cervical fluid samples were examined for the changes of pentraxin 3 (PTX3) level based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). All the cervical fluid samples had PTX3; women with MIAC, IAI, and intra-amniotic infection had its levels higher than women without these conditions. Researchers noted higher cervical fluid PTX3 levels among women with intra-amniotic infection than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. These findings suggest a potential utility of cervical fluid PTX3 as a marker for the noninvasive identification of intra-amniotic infection in PPROM.