Kindler JM, et al. - In this investigation, researchers evaluated correlations between pentosidine and cortical bone volumetric density, geometry, and projected strength in children. Otherwise healthy black and white boys and girls (ages 9 to 13 years) who were at sexual maturation stage 2 or 3 (N=160) were the participants in the study. Pentosidine was related to lower radius and tibia cortical volumetric bone mineral density, bone mineral content (Ct.BMC), area (Ct.Ar), and thickness (Ct.Th) in the unadjusted analyses. Linear regression showed a significant interaction between pentosidine and Quantitative Insulin Sensitivity Check Index (QUICKI) relative to tibia Ct.Th, signifying that the negative link between pentosidine and Ct.Th was stronger in those with lower QUICKI (ie, greater insulin resistance). This is the first study to offer evidence of the adverse effect AGEs may have on bone strength in children who are otherwise healthy. In children with the greatest insulin resistance, this link was strongest, which should warrant further study in youth with chronic metabolic health conditions.