Zheutlin AB, Dennis J, Linnér RK, et al. - Given a possible benefit of early intervention in individuals at high risk for schizophrenia, researchers investigated the utility of genetic profiling for risk stratification in clinical settings. Further, they sought to appraise the broader health consequences of high genetic risk for schizophrenia. Using electronic health records, they analyzed data of 106,160 patients from four healthcare systems and estimated the penetrance and pleiotropy of genetic risk for schizophrenia. Calculation of polygenic risk scores (PRSs) for schizophrenia was performed from summary statistics and these scores were then tested for association with 1,359 disease categories, including schizophrenia and psychosis, in phenome-wide association studies. Via meta-analysis across sites, effects were combined. Outcomes revealed a strong correlation of PRSs with schizophrenia; a 4.6-fold higher odds of schizophrenia was seen in patients in the highest risk decile of the PRS distribution vs those in the bottom decile. Furthermore, there was a positive association of PRSs with other phenotypes, including anxiety, mood, substance use, neurological, and personality disorders, as well as suicidal behavior, memory loss, and urinary syndromes.