Zheutlin AB, Dennis J, Linnér RK, et al. - Researchers tested the utility of genetic profiling, as an approach to risk stratification, in clinical settings for schizophrenia across four healthcare systems. In addition, they evaluated the broader health consequences of high genetic risk for schizophrenia. Using electronic health records, 106,160 patients from four healthcare systems were assessed for the penetrance and pleiotropy of genetic risk for schizophrenia. Calculation of polygenic risk scores (PRSs) for schizophrenia was done from summary statistics and these scores were then tested for association with 1,359 disease categories, including schizophrenia and psychosis, in phenome-wide association studies. Outcomes revealed a robust association of an available measure of genetic risk for schizophrenia with schizophrenia in healthcare settings and its pleiotropic effects on related psychiatric disorders as well as other medical syndromes. Patients in the highest risk decile of the PRS distribution vs those in the bottom decile had up to 4.6-fold higher odds of schizophrenia.