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Pembrolizumab for persistent, recurrent, or metastatic cervical cancer

New England Journal of Medicine Sep 23, 2021

Colombo N, Dubot C, Lorusso D, et al. - Patients with persistent, recurrent, or metastatic cervical cancer who were also receiving chemotherapy with or without bevacizumab, showed significantly longer progression-free and overall survival in correlation with receiving pembrolizumab vs placebo, additionally.

  • A double-blind, phase 3 trial.

  • Patients were randomly assigned to receive pembrolizumab (200 mg) or placebo every 3 weeks for up to 35 cycles plus platinum-based chemotherapy and, per investigator discretion, bevacizumab.

  • The pembrolizumab group and the placebo group had median progression-free survival of 10.4 months and 8.2 months, respectively.

  • At 24 months, the two groups had overall survival of 53.0% and 41.7%, respectively

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