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Pediatric and neonatal invasive candidiasis: Species distribution and mortality rate in a Thai tertiary care hospital

The Pediatric Infectious Disease Journal Jan 11, 2021

Jantarabenjakul W, Yodkitudomying C, Chindamporn A, et al. - Among children with underlying medical conditions, invasive candidiasis (IC) is a serious infection and a worldwide shift has been observed from C. albicans to non-albicans Candida. Researchers sought to determine species of Candida and factors linked with the overall 30-day mortality rate via performing a retrospective chart review among children with culture-confirmed IC at King Chulalongkorn Memorial Hospital, Thailand. From 2003 to 2019, there were reports of 102 episodes of IC in pediatric group with a median age of 16 months (interquartile range 4–65) and 12 episodes of IC in neonatal group with a median age of 18 days (interquartile range 12–22). Following distribution species was observed: Candida albicans (35%), Candida parapsilosis (26%), Candida tropicalis (22%), Candida glabrata (6%) and other/unspecified species (11%). This suggests diagnoses of non-albicans Candida in two-third of children with IC. Mortality rate was higher in children with neutropenia. Factors linked with 30-day mortality were: shock, thrombocytopenia and no antifungal treatment.

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