Cros J, et al. - Researchers assessed the efficacy of the first pectoral nerve block (Pecs I) for reducing postoperative pain after breast cancer surgery. They used a multimodal analgesic regimen and surgeon-administered local anesthetic infiltration for 128 patients scheduled for unilateral breast cancer surgery. They performed ultrasound-guided Pecs I using bupivacaine or saline. They mainly focused on the patient pain score (numerical rating scale [NRS]) in the recovery unit 30 minutes after admission or just before the morphine administration (NRS ≥4/10). Postoperative opioid consumption (ie, in the recovery unit and after 24 hours) was also assessed. In this study, findings demonstrated no superior efficacy of Pecs I, vs a saline placebo, in the presence of multimodal analgesia for breast cancer surgery.