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Peaks of circumpapillary retinal nerve fibre layer and associations in healthy eyes: The Beijing Eye Study 2011

British Journal of Ophthalmology Apr 19, 2021

Zhang Q, Xu L, Zhao L, et al. - Researchers conducted the study for examining the distribution and associations of the circumpapillary retinal nerve fibre layer thickness (RNFLT) profile, characterized as peak height and peak position, in healthy eyes. Six hundred sixty-seven healthy candidates (294 male) were randomly selected from the Beijing Eye Study 2011. Using spectral-domain optical coherence tomography (OCT), RNFLT was measured at 768 points at a 3.4 mm circumpapillary position. Peak RNFLT reduced by 0.34 µm for each increase of the year in age (Peak ST and Peak IT), by 3.2–3.5 µm for each 1 mm increase in axial length (all three peaks), and was 4.5 µm thinner in women than men. Gender, axial length, and Bruch’s membrane opening diameter all influenced the position of temporal peaks. Such associations should be considered in OCT-based RNFLT assessment for disease detection, particularly in glaucoma evaluation.

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