Huo J, et al. - In this investigation involving 123,066 patients, researchers studied trends in postdiagnosis depression incidence after a late-stage cancer diagnosis in racial/ethnic and sexual groups using population-based data. Study participants included patients diagnosed with late-stage breast, prostate, lung, or colorectal cancer from 2001 to 2013 in the Surveillance Epidemiology and End Results Medicare-linked database. Investigators found that depression incidence after cancer diagnosis increased from 15.3% in 2001 to 24.1% in 2013. In the first 3 months of stage IV cancer diagnosis, approximately 50% of depression was reported. Over a mean follow-up of 2.7 months, 19,775 (20.0%) non-Hispanic whites, 1937 (15.9%) non-Hispanic blacks, and 657 (12.7%) Hispanics were diagnosed with depression. Females have a significantly higher incidence of depression vs males (22.7% versus 16.3%). Being non-Hispanic whites and female still independently predicted higher risk of postdiagnosis depression, according to the multivariable logistic regression. To ensure that there is no diagnostic bias between non-Hispanic blacks and Hispanics, consideration of race and ethnicity in the prevention and diagnosis of depression among cancer patients should be discussed as an important issue.