Vives‐Mestres M, Casanova A, Buse DC, et al. - Researchers identified patterns of perceived stress across stages of the migraine cycle, within and between individuals and migraine episodes as defined for this investigation. They included patients with migraine ≥ 18 years of age who were enrolled to use the digital health platform N1‐Headache and completed 90 days of daily data entry on migraine, headache symptoms, and lifestyle factors. This research included data from 351 candidates and 2,115 episodes. Over the 90‐day period, it was noted that the mean number of migraine days per month was 6.1 and the mean number of episodes was 6.0. Perceived stress peaks during the pain phase of the migraine cycle, on an aggregate level, but there are three dominant patterns of perceived stress variation on an individual and episode basis across the migraine cycle. Insights into disease biology, triggers and protective factors can come from describing how perceived stress patterns differ across the migraine cycle; it can also offer a framework for targeting individualized treatment plans.