Patterns of medication use before, during and after pregnancy in women with systemic lupus erythematosus: A population-based cohort study
Lupus Sep 03, 2019
Zusman EZ, et al. - Via a population-based administrative data in British Columbia, Canada, with valid information on the start date of pregnancy, 284 women with SLE with 376 singleton pregnancies ending in deliveries between January 1, 2002, and December 31, 2012, were recognized by the researchers to characterize the patterns of medication use prior to, during and subsequent to the pregnancy. One or more dispensing for antimalarials, for azathioprine, for glucocorticosteroids, and for NSAIDs during pregnancy were noted in 24.2%, 8.2%, 19.7%, and 4.8%, respectively. A 16.7% discontinuation of antimalarials in the year prior to pregnancy, 29.8% in the first trimester, 9.7% in the second trimester, and 26.0% in the third trimester was discovered. The discontinuation rate of azathioprine in the first trimester, second trimester and third trimester was 29.2%, 8.0%, and 9.1%. Therefore, frequent discontinuation of medications, especially antimalarials, in SLE pregnancies was seen. These findings recommend the significance of educating women with SLE who are pregnant or planning to become pregnant on the advantages and risks of medications during pregnancy.
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