Mokhtarzadeh H, Anderson DE, Allaire BT, et al. - Researchers conducted a cross‐sectional study in a sample of adult men and women from a population‐based cohort to ascertain which activities cause the largest vertebral load‐to‐strength ratios (LSRs), and explore patterns of LSRs along the spine for these high‐load activities. Subject‐specific musculoskeletal models of the trunk were applied to ascertain vertebral compressive loads for 109 activities in 250 individuals (aged 41 to 90 years, 50% women) from the Framingham Heart Study. When evaluating vertebral LSRs, this research indicates the need to consider a range of lifting, holding, and non‐symmetric activities. Key activities that produce higher loading in multiple regions of the spine were distinguished. These outcomes give the first guidance on what activities to consider when assessing vertebral load‐to‐strength ratios in future trials, including those analyzing dynamic motions and the biomechanics of vertebral fractures.