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Patterns of antidepressant use during pregnancy: A nationwide population-based cohort study

British Journal of Clinical Pharmacology Jul 01, 2018

Bénard-Laribière A, et al. - Authors evaluated the patterns of antidepressant use during pregnancy. As per data, during pregnancy, antidepressant use was 25.7 per 1000. Before pregnancy and during the first trimester, they observed most changes: in the year before pregnancy, 63% of ongoing treatments were discontinued before conception; 68% of treatments maintained after conception were discontinued during the first trimester. Mostly the switches or antidepressant associations occurred during the periconceptional period or during the first trimester. Irrespective of the initial antidepressant, the most frequent were the switches to sertraline. In addition to a selective serotonin reuptake inhibitors (SSRIs), associations mainly consisted of a prescription of tri-/tetracyclic or mirtazapine/mianserin. In 22% of pregnancies, treatment resumption was led by discontinuation during pregnancy. In accordance with existing recommendations, pregnancy was planned or the treatment especially adapted in a large proportion of women under antidepressants or in whom such treatments have been initiated after starting a pregnancy.
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