Zadro JR, et al. - Via this longitudinal analysis, researchers examined the parent-offspring transmission of multi-site chronic pain, and whether this association is affected by lifestyle behaviors in offspring. For this work, the population-based HUNT Study (Norway) in 1995-97 and 2006-08 provided data on 7,654 offspring linked with their parents. The analysis revealed additional chronic pain sites in one-third of offspring (n = 2,573). The risk of developing additional pain sites was higher in correlation with having both parents with 1-2 chronic pain sites compared with having parents free of chronic pain, with larger effects observed when both parents had ≥ 3 chronic pain sites. Maternal pain largely drives these associations, ie, paternal chronic pain did not correlate with the risk of additional pain sites in offspring. When offspring were obese or physically inactive, they observed strengthening of the parent-offspring transfer of additional pain sites (when both parents had ≥ 3 pain sites).