Aref MW, et al. - Since patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease and fracture-associated mortality due to the accelerated bone loss, vascular calcification, and abnormal biochemistries, researchers tested if normalization of cortical bone vascular perfusion could be achieved in the setting of CKD using parathyroid hormone (PTH) suppressive interventions. In two separate experiments, intra-cardiac fluorescent microsphere injection was administered to 35-week-old CKD animals and their normal littermates to assess the effect of 10 weeks of PTH suppression (experiment 1: calcium supplementation, experiment 2: calcimimetic treatment) on alterations in bone tissue perfusion. As per outcome data, cortical bone perfusion could be normalized in the setting of CKD using PTH suppression-based interventions.