Landberg A, et al. - In a cohort of 238,788 Swedish men, researchers examined the link between adolescent body mass index (BMI) and subsequent risk of renal cell carcinoma (RCC). At a mean age of 18.5 years, participants have undergone mandatory military conscription evaluation and physical and psychological tests, including measurements of height and weight. Incident diagnoses of RCC were determined using linkage to the Swedish Cancer Registry. According to the findings, the association between overweight/obesity and RCC appeared to be already established during late adolescence. Diagnoses of RCC were reported in 266 men during a follow-up of up to 37 years. Increasing BMI during adolescence resulted in a trend for higher RCC risk. A 6% increased risk of RCC was reported in association with a one-unit increase in BMI. Hazard ratios for RCC were 1.76 and 2.87, respectively, for men with overweight (BMI 25- < 30) or obesity (BMI ≥30), compared with normal weight men (BMI 18.5- < 25).