Johnson JP, et al. - A series of fetuses with omphalocele that was tested for Beckwith-Wiedemann syndrome (BWS) was described. Researchers subsequently ascertained as to whether pregnancies were conceived by assisted reproductive technologies (ART). In fetuses with BWS/omphalocele, a 20-fold overrepresentation of in vitro fertilization (IVF) cases was observed when compared with the rate of ART pregnancies in the USA. An association of IVF and BWS was supported. They recommend counseling patients about these risks and made them aware of the availability of prenatal diagnosis for detection.